Open AWE Magazine menu
Subscribe Login

Home / Articles and Press Releases / Press Release / Quantifying the Formation of Stereoisomers On-line During an HWE Reaction Employing Benchtop NMR Spectroscopy

CATEGORIES

  • Latest Issue
  • Air Quality
  • Chromatography
  • Construction
  • Climate Change
  • Emissions
  • Environmental & Monitoring Technology
  • Gas Detection
  • Health and Safety Awareness
  • Humidity & Temperature
  • Laboratory Testing
  • Land Remediation
  • Marine Pollution
  • Noise Monitoring
  • Regulations & Legislations
  • Sludge and Biosolids
  • Soil Analysis
  • Spectroscopy
  • Weather Monitoring
  • Water Analysis
  • Water Monitoring

MORE

  • Press Releases
  • Events
  • Videos
  • Magazines

COMPANY

  • About
  • Advertising
  • Newsletter
  • Contact
HSI White logo
Open AWE Magazine menu
Subscribe

Home / Articles and Press Releases / Press Release / Quantifying the Formation of Stereoisomers On-line During an HWE Reaction Employing Benchtop NMR Spectroscopy

CATEGORIES

  • Latest Issue
  • Air Quality
  • Chromatography
  • Construction
  • Climate Change
  • Emissions
  • Environmental & Monitoring Technology
  • Gas Detection
  • Health and Safety Awareness
  • Humidity & Temperature
  • Laboratory Testing
  • Land Remediation
  • Marine Pollution
  • Noise Monitoring
  • Regulations & Legislations
  • Sludge and Biosolids
  • Soil Analysis
  • Spectroscopy
  • Weather Monitoring
  • Water Analysis
  • Water Monitoring

MORE

  • Press Releases
  • Events
  • Videos
  • Magazines

COMPANY

  • About
  • Advertising
  • Newsletter
  • Contact

CATEGORIES

  • Heat and Flame
  • Press Release|Gas Detection
  • Article
  • Press Release
  • Air Quality
  • Chromatography
  • Construction
  • Climate Change
  • Emissions
  • Environmental & Monitoring Technology
  • Gas Detection
  • Health and Safety Awareness
  • Humidity & Temperature
  • Laboratory Testing
  • Land Remediation
  • Marine Pollution
  • Noise Monitoring
  • Personal Protective Equipment
  • Regulations & Legislations
  • Sludge and Biosolids
  • Soil Analysis
  • Spectroscopy
  • Weather Monitoring
  • Water Analysis
  • Water Monitoring
  • Wellbeing at work

Press Release

Quantifying the Formation of Stereoisomers On-line During an HWE Reaction Employing Benchtop NMR Spectroscopy

By Magritek

| Read Bio

Published: November 24th, 2020

Share this article

Magritek | Benchtop NMR performance and quality

The on-line monitoring of chemical reactions employing NMR spectroscopy provides a deeper insight into the kinetics of the reaction in question and its mechanism. Several nuclei like 1H, 19F or 31P can be detected exclusively or combined in a consecutive experiment loop to follow the course of the reaction and to identify and quantify the chemical moieties of choice as well as possible intermediates or side-products. Within stereoselective synthesis, besides the conversion of the starting material the decisive step for the operator is to define the major and minor stereoisomers of the desired product and to optimize the chemical process towards complete stereoselectivity.

For the quantification of the stereoselective outcome of chemical reactions e.g. the determination of the enantiomeric excess of the reaction product, typically HPLC methods with chiral columns and reference compounds are considered. Nevertheless, when dealing with diastereoisomers as possible reaction products the quantification of the diastereomeric ratio can be determined directly by NMR spectroscopy without the need for reference compounds or a calibration. Within the following application note, we demonstrate for the first time how benchtop NMR spectroscopy can be employed to not only follow the course of a stereoselective reaction on-line but also to determine its stereochemical outcome. For this purpose, the well-known Horner-Wadsworth-Emmons reaction (HWE reaction) was selected using our latest member of the Spinsolve family the Spinsolve 80 MHz ULTRA system.

You can download the full application note through the following link: Click Here

Share this article

ABOUT THE AUTHOR

Magritek

Founded in 2004, Magritek is an advanced technology company exporting from Germany and New Zealand to customers all over the world. The initial technology and IP used in Magritek products was developed by research teams at RWTH University, Germany, and  Massey University and Victoria University of Wellington in New Zealand.

Magritek developed its flagship Spinsolve Benchtop NMR Spectrometer capable of multinuclear NMR spectroscopy, with the highest resolution and sensitivity performance on any benchtop instrument available today. Models includes the Spinsolve Carbon, the world’s first benchtop NMR Spectrometer capable of 13C NMR Spectroscopy.

Magritek also developed the Terranova-MRI, the world’s first and only 3D MRI-capable teaching system for students and teachers in a normal laboratory environment. MRI experiments can now safely be done anywhere — the Terranova-MRI uses the Earth’s magnetic field.

Magritek provides complete NMR and MRI solutions for the fine chemical, pharmaceutical, polymer, food and petrochemical industries, as well as components and subsystems suitable for research laboratories and chemistry education.

Magritek has offices in Philadelphia, USA , in Aachen, Germany and in Wellington, New Zealand.

Connect with Magritek

Visit Website

POPULAR POSTS BY Magritek

Press Release

Quantifying the Formation of Stereoisomers On-line During an HWE Reaction Employing Benchtop NMR Spectroscopy

Get email updates

Sign up for the AWE newsletter

Keep up-to-date through the power of email and receive the latest environmental monitoring product information and newsletter emails from AWE - Monitoring and Analysing the Impact of Industry on the Environment

"*" indicates required fields

Country
*
This field is for validation purposes and should be left unchanged.

FEATURED ARTICLES

Press Release

Blackline Safety and NevadaNano Reach Milestone in Deployment of Industry-First Sensors

Press Release

The Benefits of Using Refurbished Parts in Your Lab

Advertisement

SOCIAL MEDIA

AWE on Facebook

https://www.facebook.com/AWEIMagazine/

Advertisement

SOCIAL MEDIA

AWE on Twitter

Retweet on Twitter AWE International Magazine Retweeted
Avatar Avantes @avanteshq ·
1 Feb

Meet the next-generation spectrometer, the #Pacto!
This versatile and powerful device, available in three configurations, is sure to revolutionize the world of #spectroscopy.

Click the link to discover the Pacto: https://www.avantes.com/news/pacto-spectrometer-release/

https://www.youtube.com/watch?v=AZJXb-ZN4WY

Reply on Twitter 1620703609657909248 Retweet on Twitter 1620703609657909248 1 Like on Twitter 1620703609657909248 2 Twitter 1620703609657909248

Advertisement

SUBSCRIBE

Stay up to date with our newsletter

    • Keep up-to-date with Europe’s largest audited environmental monitoring magazine

 

    • Delivering the latest information on new products and emerging technologies related to industrial environmental monitoring.

 

This field is for validation purposes and should be left unchanged.

Subscribe

SUBSCRIBE TO AWE MAGAZINE

5 reasons to subscribe to our digital and print package

  • Stay up to date from anywhere in the world, with instant access to the latest issue straight from your phone, tablet or laptop.
  • Trust that you’re getting the best content from our range of internationally accredited authors.
  • Get full access to our archives and see how the environmental monitoring landscape has evolved with us over the years.
  • Enjoy our monthly newsletter curated with up-to-the-minute news and a selection of editor’s top picks.
  • Hot off the press and straight to your door – look forward to your own glossy copy of AWE, delivered five times a year
Subscribe View Subscription levels

STAY SAFE & INFORMED

Subscribe to the latest environmental monitoring articles, news, products and regulations

Find out more

Stay up to date with our newsletter

  • This field is for validation purposes and should be left unchanged.

ABOUT

  • About AWE
  • Advertise
  • Contact Us

YOUR ACCOUNT

Sign In Register Account Subscribe to AWE

RESOURCES

Request Media Pack

CONNECT

ACCREDITATIONS

Copyright Bay Publishing 2023. All Rights reserved.

Designed & Built by:
  • Terms & Conditions
  • Privacy Policy
  • Cookie Policy
We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept”, you consent to the use of ALL the cookies.
Cookie settingsACCEPT
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
SAVE & ACCEPT