Open AWE Magazine menu
Subscribe Login

Home / Articles and Press Releases / Press Release / LAUDA Provides Temperature Control at -80 °C for Freeze-Dryer

CATEGORIES

  • Latest Issue
  • Air Quality
  • Chromatography
  • Construction
  • Climate Change
  • Emissions
  • Environmental & Monitoring Technology
  • Gas Detection
  • Health and Safety Awareness
  • Humidity & Temperature
  • Laboratory Testing
  • Land Remediation
  • Marine Pollution
  • Noise Monitoring
  • Regulations & Legislations
  • Sludge and Biosolids
  • Soil Analysis
  • Spectroscopy
  • Weather Monitoring
  • Water Analysis
  • Water Monitoring

MORE

  • Press Releases
  • Events
  • Videos
  • Magazines
  • Webinar Sign Up

COMPANY

  • About
  • Advertising
  • Newsletter
  • Contact
HSI White logo
Open AWE Magazine menu
Subscribe

Home / Articles and Press Releases / Press Release / LAUDA Provides Temperature Control at -80 °C for Freeze-Dryer

CATEGORIES

  • Latest Issue
  • Air Quality
  • Chromatography
  • Construction
  • Climate Change
  • Emissions
  • Environmental & Monitoring Technology
  • Gas Detection
  • Health and Safety Awareness
  • Humidity & Temperature
  • Laboratory Testing
  • Land Remediation
  • Marine Pollution
  • Noise Monitoring
  • Regulations & Legislations
  • Sludge and Biosolids
  • Soil Analysis
  • Spectroscopy
  • Weather Monitoring
  • Water Analysis
  • Water Monitoring

MORE

  • Press Releases
  • Events
  • Videos
  • Magazines
  • Webinar Sign Up

COMPANY

  • About
  • Advertising
  • Newsletter
  • Contact

CATEGORIES

  • Heat and Flame
  • Press Release|Gas Detection
  • Article
  • Press Release
  • Air Quality
  • Chromatography
  • Construction
  • Climate Change
  • Emissions
  • Environmental & Monitoring Technology
  • Gas Detection
  • Health and Safety Awareness
  • Humidity & Temperature
  • Laboratory Testing
  • Land Remediation
  • Marine Pollution
  • Noise Monitoring
  • Personal Protective Equipment
  • Regulations & Legislations
  • Sludge and Biosolids
  • Soil Analysis
  • Spectroscopy
  • Weather Monitoring
  • Water Analysis
  • Water Monitoring
  • Wellbeing at work

Press Release

LAUDA Provides Temperature Control at -80 °C for Freeze-Dryer

By LAUDA

| Read Bio

Published: September 22nd, 2020

Share this article

LAUDA, the world market leader for temperature control equipment and systems, has been manufacturing customer-specific refrigeration systems for  pharmaceutical companies for more than 50 years. The company has now completed a cryogenic cooling system for use in a pharmaceutical freeze-drying plant. This enables pharmaceutical substances to be gently frozen at -80°C.

The order was placed by Martin Christ Gefriertrocknungsanlagen GmbH, one of the world’s leading freeze-dryer companies with more than 70 years of experience in this field. Martin Christ relies on the expertise of LAUDA for the reliable provision of the deep-freeze environment. A Kryopac Secondary Circuit Unit from LAUDA Heating and Cooling Systems, the plant construction division of the temperature control specialist, which plans and manufactures exactly according to customer requirements, provides the requisite cooling capacity.

Drugs and vaccines are essential for the treatment of diseases and the health of people worldwide. Since many drugs would only have a short shelf life when dissolved in water, the pharmaceutical industry relies on gentle freeze-drying for longer preservation. LAUDA was quickly chosen as the cryogenics expert for Martin Christ for the manufacture of a freeze-drying plant for an international pharmaceutical company. Apart from LAUDA’s comprehensive know-how, the two companies have enjoyed a successful working relationship for many years. “We are specialists for extremely low temperatures and have been able to gain valuable experience in this field over many years”, emphasizes Ralph Herbert, the project manager for Heating and Cooling Systems.

Liquid nitrogen provides temperatures down to -115 °C

Precise temperature control for the freeze-dryer is provided by a LAUDA Kryopac Secondary Circuit Unit, which enables cryogenic reactions to be safely controlled. The possibility of individual temperature control of the shelves and the ice condenser is of great importance in this refrigeration system. But the Kryopac, a heat exchanger specially developed for the evaporation of liquid nitrogen, is the heart of the system. Liquid nitrogen boils at -196 °C and is therefore particularly suitable as a refrigerant for applications which require extremely low temperatures. Depending on the design of the Kryopac system, temperatures down to -115 °C are possible in the secondary refrigerant oil circuit. The -80 °C required for the freeze-dryer is therefore reached quickly and exactly to the degree. Liquid nitrogen is also a non-flammable refrigerant which is preferred not only by the end customer but also by the pharmaceutical industry in general. Other advantages include economic, safety and environmental aspects, such as low investment costs and lack of waste products. Depending on the specification of the application, the nitrogen requirement can be decreased by adapting the control system designed by LAUDA, thereby significantly reducing operating costs.

The heat technology of the Kryopac system is derived from the proven LAUDA Heat Transfer Units used by many customers. These produce a temperature-controlled liquid flow and are delivered as a compact, fully insulated, ready-to-connect system with a control cabinet. The benefit: There are no freezing problems in the heat exchangers here. Precise temperature control, compact design and high plant availability were particularly important for Martin Christ’s customer. The LAUDA Kryopac Secondary Circuit Unit also meets these requirements without any problems.

Freeze-drying makes use of a physical phenomenon

Freeze-drying is an extremely gentle preservation method, as the chemical properties of the source substances are not changed. All the active ingredients in pharmaceutical products are therefore preserved. This type of preservation is also used for sample preparation in laboratories, in the food industry or archeology, for example to preserve wet leather or wood.

The refrigeration system of the Kryopac system cools the shelves on which vessels filled with drugs are placed with a cooling capacity of 30 kW at – 80 °C and freezes the pharmaceuticals in two and a half hours. Heat is supplied during evacuation, the removal of air by creating a vacuum. This results in a physical phenomenon called sublimation: The frozen water evaporates without liquefying. The drug is dried directly from the frozen state. The resulting water vapor is deposited on the ice condenser of the freeze-dryer in the form of ice crystals. The ice condenser is maintained at a temperature of -80 °C by the Kryopac system. A complete freeze-drying process typically takes 48 hours.

The Kryopac system was initially completely tested at LAUDA and then subjected to a further thorough inspection as a complete system at Martin Christ before the freeze-dryer was delivered to the end customer. However, this is not the end of the cooperation. As a result of the successful working relationship and implementation of this project, Martin Christ has already ordered two more LAUDA Kryopac Secondary Circuit Units.

Share this article

ABOUT THE AUTHOR

LAUDA

Precise temperature control.

Lauda’s constant temperature equipment and heating and cooling systems are at the heart of many applications.

A full-service provider, Lauda guarantee the optimum temperature in research, production and quality control.

Connect with LAUDA

Visit Website

POPULAR POSTS BY LAUDA

FUTURE INVESTMENT IN COOLING SOLUTIONS WITHOUT REFRIGERANTS

Press Release

Future Investment in Cooling Solutions Without Refrigerants

Press Release

Precise Temperature Control in the Digital Age

Lauda’s First Overseas Employee Honoured With Award

Press Release

Lauda’s First Overseas Employee Honoured With Award

Italian agency DELO receives LAUDA Award

Press Release

Italian agency DELO receives LAUDA Award

Shining Example Of International Collaboration

Press Release

First LAUDA agency Beun de Ronde is awarded the Dr. Rudolf Wobser Medal

Investment in the Future of Industrial Temperature Control Technology

Press Release

Investment in the Future of Industrial Temperature Control Technology

Get email updates

Sign up for the AWE newsletter

Keep up-to-date through the power of email and receive the latest environmental monitoring product information and newsletter emails from AWE - Monitoring and Analysing the Impact of Industry on the Environment

"*" indicates required fields

Country
*
This field is for validation purposes and should be left unchanged.

FEATURED ARTICLES

Press Release

Blackline Safety and NevadaNano Reach Milestone in Deployment of Industry-First Sensors

Press Release

The Benefits of Using Refurbished Parts in Your Lab

Advertisement

SOCIAL MEDIA

AWE on Facebook

https://www.facebook.com/AWEIMagazine/

Advertisement

SOCIAL MEDIA

AWE on Twitter

Avatar @ ·
now

Reply on Twitter Retweet on Twitter Like on Twitter Twitter

Advertisement

SUBSCRIBE

Stay up to date with our newsletter

    • Keep up-to-date with Europe’s largest audited environmental monitoring magazine

 

    • Delivering the latest information on new products and emerging technologies related to industrial environmental monitoring.

 

This field is for validation purposes and should be left unchanged.

Subscribe

SUBSCRIBE TO AWE MAGAZINE

5 reasons to subscribe to our digital and print package

  • Stay up to date from anywhere in the world, with instant access to the latest issue straight from your phone, tablet or laptop.
  • Trust that you’re getting the best content from our range of internationally accredited authors.
  • Get full access to our archives and see how the environmental monitoring landscape has evolved with us over the years.
  • Enjoy our monthly newsletter curated with up-to-the-minute news and a selection of editor’s top picks.
  • Hot off the press and straight to your door – look forward to your own glossy copy of AWE, delivered five times a year
Subscribe View Subscription levels

STAY SAFE & INFORMED

Subscribe to the latest environmental monitoring articles, news, products and regulations

Find out more

Stay up to date with our newsletter

  • This field is for validation purposes and should be left unchanged.

ABOUT

  • About AWE
  • Advertise
  • Contact Us

YOUR ACCOUNT

Sign In Register Account Subscribe to AWE

RESOURCES

Request Media Pack

CONNECT

ACCREDITATIONS

Copyright Bay Publishing 2023. All Rights reserved.

Designed & Built by:
  • Terms & Conditions
  • Privacy Policy
  • Cookie Policy
We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept”, you consent to the use of ALL the cookies.
Cookie settingsACCEPT
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
SAVE & ACCEPT